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- Title
Comparison of magnetic resonance imaging findings in Alzheimer's, lewy body, frontotemporal and vascular dementia types.
- Authors
Özcan, Ayşegül; Karataş, Turgay
- Abstract
Objective: The study aimed to compare demographic data, body mass index (BMI), hemoglobin values (Hgb), accompanying diseases (DM, stroke, etc.), B12 values, and MRI findings of patients diagnosed with Alzheimer's disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VD). Methods: This retrospective study included 21 patients in each group diagnosed with Alzheimer's, lewy body, frontotemporal, and vascular dementia, totaling 84 individuals. Demographic data, BMI, accompanying diseases, hemoglobin, B12 values, and MRI findings were evaluated. Results: Dementia patients had an average age of 81±5.57 years. BMI indicated that 58% had a BMI <20 kg/m², and 8% <18.5 kg/m². B12 <200 pg/mL was found in 90.4% of AD patients. 61.9% had low Hgb. Vascular dementia had a significantly higher DM diagnosis than other groups (p=0.002). LBD had significantly fewer SVO diagnoses than other groups (p<0.001). AD showed more frequent hippocampal atrophy and sulcal deepening than other dementia types (p<0.001). LBD had more subcortical atrophy and substantia nigra lesion findings than other types (p<0.001). VD exhibited more multifocal lesions and microhemorrhages than other types (p<0.001). FTD had more frequent frontal and temporoparietal lobe atrophy than other dementia types (p<0.05). Conclusion: Each dementia type exhibited more frequent atrophy in specific locations; for example, AD had common hippocampal atrophy, while FTD had more frequent frontal and temporal atrophy. LBD showed more subcortical involvement, and VD exhibited multifocal lesions associated with vasculopathy.
- Subjects
ALZHEIMER'S disease; VASCULAR dementia; FRONTOTEMPORAL dementia; LEWY body dementia; MAGNETIC resonance imaging
- Publication
Anatomy: International Journal of Experimental & Clinical Anatomy, 2024, Vol 18, pS4
- ISSN
1307-8798
- Publication type
Abstract