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- Title
Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs.
- Authors
Vargas-Calla, Ana; Gomez-Puerta, Luis A.; Calcina, Juan; Gonzales-Viera, Omar; Gavidia, Cesar; Lopez-Urbina, Maria T.; Garcia, Hector H.; Gonzalez, Armando E.
- Abstract
Objective To assess the efficacy of triclabendazole (TCBZ) in porcine cysticercosis. Methods Eighteen naturally infected cysticercosis pigs were divided into 3 groups of 6 individuals each. The first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight, the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo (control group). All animals were kept under the same management conditions. The pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between groups. Results All pigs treated with oxfendazole had only degenerated cysts in their carcasses. In contrast, TCBZ had very little effect against the parasitic cysts. Cysts from pigs in the TCBZ group looked apparently normal after treatment. However, histological evaluation showed a mild to moderate degree of inflammation. Conclusions TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.
- Publication
Asian Pacific Journal of Tropical Medicine, 2016, Vol 9, Issue 1, p23
- ISSN
1995-7645
- Publication type
Article
- DOI
10.1016/j.apjtm.2015.12.005