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- Title
Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?
- Authors
Sørensen, Christoffer V.; Knudsen, Cecilie; auf dem Keller, Ulrich; Kalogeropoulos, Konstantinos; Gutiérrez-Jiménez, Cristina; Pucca, Manuela B.; Arantes, Eliane C.; Bordon, Karla C. F.; Laustsen, Andreas H.
- Abstract
Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management and require further examination.
- Subjects
SNAKE venom; PROTEOLYTIC enzymes; ANTIBIOTICS; BACTERIAL diseases; AMINO acid oxidase; SERINE proteinases
- Publication
Toxins, 2020, Vol 12, Issue 4, p240
- ISSN
2072-6651
- Publication type
Article
- DOI
10.3390/toxins12040240