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- Title
Clinical and immunological relevance of anti-neuronal antibodies in celiac disease with neurological manifestations.
- Authors
Caio, Giacomo; De Giorgio, Roberto; Venturi, Alessandro; Giancola, Fiorella; Latorre, Rocco; Boschetti, Elisa; Serra, Mauro; Ruggeri, Eugenio; Volta, Umberto
- Abstract
Aim: To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (CD) patients. Background: Neurological manifestations are estimated to occur in about 10% of celiac disease patients and NA to central nervous system (CNS) and enteric nervous system (ENS) are found in a significant proportion of them. Little is known about the clinical and immunological features in CD patients with neurological manifestations. Patients and methods: NA to CNS and ENS were investigated in 106 CD patients and in 60 controls with autoimmune disorders by indirect immunofluorescence on rat / primate cerebellar cortex and intestinal (small and large bowel) sections. Results: IgG NA to CNS (titer 1:50 - 1:400) were positive in 23 celiacs (21%), being more frequently detected in those with neurological disorders that in those without neurological dysfunction (49% vs. 8%, P< 0.0001). Of the 26 celiacs (24%) with IgG NA to ENS, 11 out of 12 with an antibody titer > 1:200 had severe constipation. Only one patient with cerebellar ataxia and intestinal sub-occlusion was positive for NA to CNS and ENS. NA to CNS and ENS were found in 7% and 5% of controls, respectively. Conclusion: In CD the positivity of NA to CNS can be regarded as a marker of neurological manifestations. High titer NA to ENS are associated with severe constipation. The demonstration of NA to CNS and ENS suggests an immune- mediated pathogenesis leading to central neural impairment as well as gut dysfunction (hence constipation), respectively.
- Subjects
CELIAC disease diagnosis; DIAGNOSIS of neurological disorders; AUTOANTIBODIES; CALCIUM; CELL physiology; CENTRAL nervous system; CHRONIC diseases; FISHER exact test; FLUORESCENT antibody technique; GASTROENTEROLOGY; GLUTAMINE; IMMUNITY; NEUROLOGIC manifestations of general diseases; DATA analysis
- Publication
Gastroenterology & Hepatology from Bed to Bench, 2015, Vol 8, Issue 2, p146
- ISSN
2008-2258
- Publication type
Article