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- Title
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.
- Authors
Espinoza, Ingrid; Pochampally, Radhika; Fei Xing; Watabe, Kounosuke; Miele, Lucio
- Abstract
Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the "stemness" program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.
- Subjects
ONCOLOGY; CANCER stem cells; MESENCHYMAL stem cells; EPITHELIAL cells; NEOVASCULARIZATION inhibitors; METASTASIS
- Publication
OncoTargets & Therapy, 2013, Vol 6, p1249
- ISSN
1178-6930
- Publication type
Article
- DOI
10.2147/OTT.S36162