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- Title
Two New Phorbol-Type Diterpene Esters from Synadenium grantii Hook F. Leaves.
- Authors
Hassan, Emad M.; Mohammed, Magdy M. D.; Mohamed, Samy M.
- Abstract
Abstract: Two new phorbol-type diterpene esters have been isolated from the chloroform extract of the leaves of Synadenium grantii Hook F. and identified as 3,4,12,13-tetraacetylphorbol-20-phenylacetate and 4- deoxyphorbol-12,13-ditiglate for which the trivial names Synagrantol A & B respectively, were adopted. Furthermore, two known triterpenes were isolated. The structures of all isolated compounds were established by 1D and 2D NMR spectroscopy including ¹H and 13C NMR, HSQC and HMBC techniques. The cytotoxicity as well as the antiparasitic activity of the chloroform extract was performed and proved to be active.
- Subjects
PHORBOLS; DITERPENES; ESTERS; PLANT extracts; CHLOROFORM; LEAVES; CELL-mediated cytotoxicity; ANTIPARASITIC agents
- Publication
Records of Natural Products, 2012, Vol 6, Issue 3, p255
- ISSN
1307-6167
- Publication type
Article