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- Title
Hydroalcoholic Extract of Ziziphus Jujuba Leaf to Prevent Ethylene Glycol and Ammonium Chloride-Induced Kidney Stones in Male Rat: Is it Effective?
- Authors
Pourahmadi, Mohammad; Fathi, Mehran; Rahimipour, Marzieh; Shaterian, Negar; Jahromi, Hossein Kargar
- Abstract
Purpose: This study aimed to evaluate the effect of Ziziphus jujuba (Z. jujuba) leaf hydroalcoholic extract on the prevention/treatment of kidney stones. Materials and Methods: Thirty-six male Wistar rats were randomly divided into six groups: control, Sham (kid- ney stone induction (KSI) by ethylene glycol 1% + ammonium chloride 0.25% through drinking water for 28 days), Prevention groups 1, 2 (KSI and Z. jujuba leaf (250 and 500 mg/kg, respectively) through gavage for 28 days), and Treatment groups 1, 2 (KSI and Z. jujuba leaf (250 and 500 mg/kg, respectively) from the 15th day). On the 29th day, the rats’ 24-hour urine was assessed, the animals were weighed, and blood samples were taken. Finally, after nephrectomy and weighing the kidneys, tissue sections were prepared to examine the number of cal- cium oxalate crystals and tissue changes. Results: The results indicated a significant increase in kidney weight and index, tissue changes, and the number of calcium oxalate crystals in the Sham group compared to the control; using Z. jujuba leaf considerably reduced them in experimental groups compared to the Sham. Body weight decreased in the Sham and experimental groups (except the prevention 2 group) compared to the control, while this observed reduction was lower in all experimen- tal groups compared to the Sham. The mean urinary calcium, uric acid, creatinine, and serum creatinine in Sham and experimental groups (except the prevention 2 group) indicated a substantial increase compared to the control and decreased significantly in all experimental groups compared to the Sham. Conclusion: Hydroalcoholic extract of Z. jujuba leaf is effective in the reduction of calcium oxalate crystals form- ing, and its most effective dose was 500mg/kg.
- Subjects
JUJUBE (Plant); ETHYLENE glycol; KIDNEY stones; CALCIUM oxalate; GINGER; AMMONIUM chloride
- Publication
Urology Journal, 2023, Vol 20, Issue 6, p397
- ISSN
1735-1308
- Publication type
Article
- DOI
10.22037/uj.v20i.7347]