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- Title
Recurrent hemichorea in an adolescent with systemic lupus erythematosus and previous ipsilateral cerebral infarction.
- Authors
Yu, Ya‐Wen; Chung, Cheng‐Yu; Chiou, Yee‐Hsuan; Fang, Nai‐Wen
- Abstract
Systemic lupus erythematosus (SLE) can present with movement disorders, among which chorea is closely associated with antiphospholipid (aPL) antibodies. Brain imaging results obtained in patients with chorea are generally inconsistent with the clinical manifestation of chorea; moreover, medical tests for hemichorea, which are expected to reveal distinct localization, may show negative findings. Herein, we present a case of a 15‐year‐old girl with SLE who had a history of left cerebral infarction; tests revealed elevated aPL levels, and she developed recurrent left hemichorea 2 years later. Brain magnetic resonance imaging (MRI) results revealed no acute lesions during each episode of involuntary movements, and an MRI perfusion scan failed to provide an explanation for the asymmetric presentation. Although various hypotheses have been proposed regarding the mechanism underlying the occurrence of chorea, some scenarios still remain unexplained. Further investigation on the pathophysiology of chorea in SLE may be warranted to clarify its prognosis.
- Subjects
SYSTEMIC lupus erythematosus; MOVEMENT disorders; CEREBRAL infarction; MAGNETIC resonance imaging; TREATMENT effectiveness; SYMPTOMS; CHOREA
- Publication
International Journal of Rheumatic Diseases, 2024, Vol 27, Issue 1, p1
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.14886