We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosisEZSCAN 检测自主神经功能紊乱与亚临床动脉粥样硬化相关性研究
- Authors
Sun, Jichao; Zhang, Yinfei; Xu, Baihui; Lv, Xiaofei; Ding, Lin; Chen, Ying; Sun, Wanwan; Lu, Jieli; Xu, Min; Bi, Yufang; Ning, Guang
- Abstract
Background The present study aimed to explore the association between autonomic dysfunction and measurements of atherosclerosis in a middle-aged and elderly Chinese population. Methods A population-based cross-sectional study was performed in Shanghai, China, from March to August 2010, with 5076 participants included in the analysis. Autonomic function was assessed by a novel EZSCAN test based on sudomotor function analysis. Carotid intima-media thickness ( CIMT) was measured using B-mode ultrasonography and brachial-ankle pulse wave velocity (ba- PWV) was measured using an autonomic device. Participants were divided into three groups based on EZSCAN values: Group 1: EZSCAN 0-24; Group 2, EZSCAN 25-49; and Group 3, EZSCAN 50-100. These groups denoted autonomic dysfunction risk groups as follows: no risk, moderate risk and high risk, respectively. Results The prevalence of elevated CIMT and ba- PWV increased markedly with increasing EZSCAN values (elevated CIMT 7.4%, 17.5%, and 29.7%, elevated ba- PWV 3.2%, 19.7%, and 36.5%, in Groups 1, 2, and 3, respectively; both Ptrend < 0.0001). Logistic regressions revealed that EZSCAN values ≥50 were associated with a non-significantly higher risk of elevated CIMT (odds ratio [OR] = 1.43; 95% confidence interval [ CI] 0.98-2.07) and a significantly higher risk of elevated ba- PWV (OR = 2.16; 95% CI 1.25-3.71) compared with EZSCAN values <25, after controlling for conventional risk factors. Conclusion A higher EZSCAN value (≥50), an index of high autonomic dysfunction risk, was associated with an increased risk of elevated ba- PWV and CIMT. Such associations were partially explained by traditional atherosclerotic risk factors.
- Subjects
DYSAUTONOMIA; ATHEROSCLEROSIS; CAROTID intima-media thickness; CARDIOVASCULAR disease diagnosis; CAROTID artery physiology
- Publication
Journal of Diabetes, 2014, Vol 6, Issue 5, p409
- ISSN
1753-0393
- Publication type
Article
- DOI
10.1111/1753-0407.12135