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- Title
Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior.
- Authors
Giacomin, Paul R; Kraeuter, Ann Katrin; Albornoz, Eduardo A; Jin, Shuting; Bengtsson, Mia; Gordon, Richard; Woodruff, Trent M; Urich, Tim; Sarnyai, Zoltán; Magalhães, Ricardo J Soares; Sarnyai, Zoltán; Soares Magalhães, Ricardo J
- Abstract
Helminth infections in children are associated with impaired cognitive development; however, the biological mechanisms for this remain unclear. Using a murine model of gastrointestinal helminth infection, we demonstrate that early-life exposure to helminths promotes local and systemic inflammatory responses and transient changes in the gastrointestinal microbiome. Behavioral and cognitive analyses performed 9-months postinfection revealed deficits in spatial recognition memory and an anxiety-like behavioral phenotype in worm-infected mice, which was associated with neuropathology and increased microglial activation within the brain. This study demonstrates a previously unrecognized mechanism through which helminth infections may influence cognitive function, via perturbations in the gut-immune-brain axis.
- Publication
Journal of Infectious Diseases, 2018, Vol 217, Issue 4, pN.PAG
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy092