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- Title
Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection.
- Authors
Houser, Katherine V.; Lisa Gretebeck; Tianlei Ying; Yanping Wang; Leatrice Vogel; Lamirande, Elaine W.; Bock, Kevin W.; Moore, Ian N.; Dimitrov, Dimiter S.; Kanta Subbarao; Gretebeck, Lisa; Ying, Tianlei; Wang, Yanping; Vogel, Leatrice; Subbarao, Kanta
- Abstract
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40-9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.
- Subjects
PREVENTIVE medicine; EUROPEAN rabbit; RABBITS; SARS disease; RABBIT breeds
- Publication
Journal of Infectious Diseases, 2016, Vol 213, Issue 10, p1557
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw080