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- Title
Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
- Authors
Iizuka, Katsumi; Takeda, Jun; Horikawa, Yukio
- Abstract
Abstract: Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (−2000 to +65bp) revealed a glucose responsive region between −74 and −52bp. These findings suggest that FGF21 expression is regulated by ChREBP.
- Subjects
GLUCOSE; GENE expression; MESSENGER RNA; LIVER cells; LABORATORY rats; FIBROBLAST growth factors; CARRIER proteins; CARBOHYDRATES
- Publication
FEBS Letters, 2009, Vol 583, Issue 17, p2882
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.07.053