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- Title
The FoxO transcription factors and metabolic regulation
- Authors
Nakae, Jun; Oki, Miyo; Cao, Yongheng
- Abstract
Abstract: Forkhead transcription factors FoxOs are conserved beyond species and regulated by insulin signaling pathway. FoxOs have diverse functions on differentiation, proliferation and cell survival. In calorie restriction (CR) or starvation, FoxOs are in nucleus, active transcriptionally, and increase hepatic glucose production, decrease insulin secretion, increase food intake and cause degradation of skeletal muscle for supplying substrates for glucose production. However, even in insulin resistance due to excessive calorie intake, FoxOs are active and causes type 2 diabetes and hyperlipidemia. The understanding of molecular mechanism how FoxOs affect glucose or lipid metabolism will shed light on the novel therapy of type 2 diabetes and the metabolic syndrome.
- Subjects
METABOLIC regulation; INSULIN; CELLS; PHYSIOLOGICAL control systems
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p54
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.025