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- Title
Stg1 is a novel SM22/transgelin-like actin-modulating protein in fission yeast
- Authors
Nakano, Kentaro; Bunai, Fumihide; Numata, Osamu
- Abstract
Abstract: We identified a novel actin-modulating protein Stg1 in the fission yeast Schizosaccharomyces pombe. Stg1 is similar to mammalian SM22/transgelin, and biochemical experiments showed that Stg1 crosslinked F-actin. Microscopic observation suggested that Stg1 was a component of actin patch. Overexpression of Stg1 caused a defect in cytokinesis by suppressing the formation of a contractile ring and formation of abnormal aggregates of F-actin in the ends and mid-region of cells. Although distribution of the actin cytoskeleton was not affected by disrupting stg1 +, genetic interaction suggested that Stg1 was likely involved in controlling the organization of the actin cytoskeleton in cell morphogenesis and cytokinesis in fission yeast.
- Subjects
ACTIN; CYTOPLASM; CELL division; YEAST
- Publication
FEBS Letters, 2005, Vol 579, Issue 28, p6311
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.10.011