We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protein A – a new ligand for human C-reactive protein
- Authors
Das, Tanusree; Mandal, Chhabinath; Mandal, Chitra
- Abstract
Phosphorylcholine (PC) is a classical ligand of C-reactive protein (CRP), a clinically important acute phase protein. In search of new ligands, CRPs were affinity-purified from several pathological samples, which exhibited distinct molecular variants induced in different diseases. Both glycosylated and non-glycosylated CRPs showed calcium-independent differential-binding to Staphylococcus aureus cell-surface Protein A. CRP possesses separate binding sites for Protein A and PC with different binding constants. We have demonstrated that Protein A is another ligand in addition to PC establishing an extended definition of CRP. Protein A binding may impart immunomodulatory roles of CRP in combating microorganisms or other foreign materials.
- Subjects
PROTEINS; MICROORGANISMS; MICROBIOLOGY; ALKALOPHILIC microorganisms
- Publication
FEBS Letters, 2004, Vol 576, Issue 1/2, p107
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.08.072