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- Title
Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema.
- Authors
Gärdenfors, F.; Nilsson, A.; Ungerstedt, U.; Nordström, C. H.; Gärdenfors, F; Nordström, C H
- Abstract
<bold>Background: </bold>Prostacyclin (PGI2) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low-dose PGI2 in an experimental model of vasogenic brain oedema.<bold>Methods: </bold>Twenty-seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI2 (1 ng kg(-1) min(-1)) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low-dose infusion of PGI2 started 1 h before the LPS injection and was constant during the study period.<bold>Results: </bold>Intracranial pressure increased significantly in animals treated with PGI2. The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol.<bold>Conclusion: </bold>In LPS-induced brain oedema i.v. infusion of low-dose PGI2 caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes.
- Subjects
PROSTACYCLIN; VASODILATORS; PHARMACODYNAMICS; CEREBRAL edema; BRAIN diseases; INJECTIONS; MICRODIALYSIS
- Publication
Acta Anaesthesiologica Scandinavica, 2004, Vol 48, Issue 10, p1316
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1111/j.1399-6576.2004.00522.x