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- Title
Vasostatins: new molecular targets for atherosclerosis, post-ischaemic angiogenesis, and arteriogenesis.
- Authors
Madonna, Rosalinda; Barachini, Serena; Ghelardoni, Sandra; Lu, Lin; Shen, Wei-Feng; Caterina, Raffaele De
- Abstract
The chromogranin–secretogranin secretory proteins—granins—are acidic proteins localized in granules of endocrine cells and neurons. The chromogranin family includes chromogranins A (CgA) and B, as well as secretogranin II (once called chromogranin C). Members of this family undergo catalytic proteolysis to produce active peptides. The CgA-derived peptides vasostatin-1 and vasostatin-2, in particular, appear to protect against atherosclerosis, suppressing the expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1, as well as exerting vasodilatory effects by enhancing nitric oxide bioavailability. Vasostatin-1 also suppresses vasoconstriction and abnormal angiogenesis. Vasostatin-1 and vasostatin-2 may be novel therapeutic targets for atherosclerosis and coronary heart disease, also protecting the myocardium against ischaemic damage.
- Subjects
VASCULAR cell adhesion molecule-1; DRUG target; ENDOCRINE cells; IMMOBILIZED proteins; NEOVASCULARIZATION; CELL adhesion
- Publication
Cardiovascular Research, 2024, Vol 120, Issue 2, p132
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvae008