We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma.
- Authors
Yin-Yin Chiang; Yung-Chih Chou; Kai-Ping Chang; Chun-Ta Liao; Yao-Yu Wu; Wing-Keen Yap; Ping-Ching Pai; Joseph Tung-Chieh Chang; Chien-Yu Lin; Kang-Hsing Fan; Bing-Shen Huang; Tsung-Min Hung; Ngan-Ming Tsang; Chiang, Yin-Yin; Chou, Yung-Chih; Chang, Kai-Ping; Liao, Chun-Ta; Wu, Yao-Yu; Yap, Wing-Keen; Pai, Ping-Ching
- Abstract
<bold>Background: </bold>We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).<bold>Methods: </bold>The study sample consisted of 905 patients with surgically treated OCSCC who fulfilled criteria of RT course ≤8 weeks. The study participants were divided into three groups based on the characteristics of missed RT, as follows: 1) early missed RT, 2) late missed RT, and 3) RT as scheduled.<bold>Results: </bold>The 5-year overall survival (OS) rates in the early missed RT, late missed RT, and RT as scheduled groups were 53.0, 58.1, and 64.5%, respectively (p = 0.046). In multivariate analysis, early missed RT was independently associated with both OS (hazard ratio (HR) = 1.486; 95% confidence interval (CI): 1.122-1.966; p = 0.006) and the occurrence of distant metastasis (HR = 1.644; 95% CI: 1.047-2.583; p = 0.031).<bold>Conclusion: </bold>Early missed RT was independently associated with a higher occurrence of distant metastasis and less favorable OS in patients who had undergone surgery for OCSCC.
- Subjects
SQUAMOUS cell carcinoma; METASTASIS; TREATMENT delay (Medicine); CANCER prognosis; CANCER radiotherapy; ORAL cancer; ONCOLOGIC surgery
- Publication
Radiation Oncology, 2020, Vol 15, p1
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-020-01632-1