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- Title
Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention.
- Authors
Laimer, M.; Ebenbichler, C.F.; Kaser, S.; Sandhofer, A.; Weiss, H.; Nehoda, H.; Aigner, F.; Patsch, J.R.
- Abstract
BACKGROUND: Human adipose tissue expresses and releases proinflammatory cytokines and these measures of chronic inflammation have recently been associated with obesity. HYPOTHESIS: To test whether the proinflammatory state is reversible in subjects undergoing weight loss by surgical measures. SUBJECTS AND METHODS: Twenty morbidly obese women participated in this prospective study. Subjects were examined for fat mass, high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) before and 1 y after Swedish adjustable gastric banding. RESULTS: Anthropometric measures displayed a significant reduction of the body mass index (BMI) from 41.6±5.4 to 30.8±6.1 kg/m² and the fat mass from 53.9 ± 10.3 to 29.8 ± 12.1 kg (mean ± s.d.). Hs-CRP levels decreased significantly from 1.33 ± 1.21 mg/dl in pre-gastric banding subjects to 0.40 ± 0.61 mg/dl in post-gastric banding subjects, respectively. IL-6 and TNF-α levels did not differ significantly between pre- and post-gastric banding subjects. CONCLUSIONS: We speculate that in these patients the marked reduction in C-reactive protein might be beneficial in reducing their cardiovascular risk and is not solely mediated by IL-6 and TNF-α.
- Subjects
OBESITY in women; INFLAMMATION; CYTOKINES; C-reactive protein; INTERLEUKIN-6
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2002, Vol 26, Issue 5, p659
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801970