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- Title
Plasmablastic Lymphomas With MYC/IgH Rearrangement: Report of Three Cases and Review of the Literature.
- Authors
Agata M. Bogusz
- Abstract
We report detailed clinicopathologic features of 3 cases of plasmablastic lymphoma (PBL) with MYC/IgH rearrangement, representing one third of PBL cases diagnosed at our institution. This study brings the total number of reported cases in the literature to 6. All patients were HIV+ with very low CD4 counts at diagnosis. The involved locations were mediastinum, anus, and bone marrow. Tumors exhibited predominantly immunoblastic/plasmablastic morphologic features and had a plasma cell–like immunophenotype. Bright CD38 expression by flow cytometry had a tendency to be more common in these cases compared with PBL without MYC rearrangement. All cases were positive for Epstein-Barr virus–encoded RNA but lacked human herpesvirus-8 latent nuclear antigen. The 2 patients with follow-up died within 3 months. These findings show that PBL is often associated with MYC/IgH rearrangements and that this finding may portend an aggressive clinical course, suggesting that cytogenetic studies should be routinely applied in cases of PBL.
- Subjects
LYMPHOMA diagnosis; MYC oncogenes; GENE rearrangement; HIV; MEDIASTINAL tumors; BONE marrow cancer; PLASMA cell leukemia; FLOW cytometry
- Publication
American Journal of Clinical Pathology, 2009, Vol 132, Issue 4, p597
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1309/AJCPFUR1BK0UODTS