We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improving bone health in men with prostate cancer receiving androgen deprivation therapy: Results of a randomized phase 2 trial.
- Authors
Alibhai, Shabbir M. H.; Breunis, Henriette; Timilshina, Narhari; Hamidi, Maryam S.; Cheung, Angela M.; Tomlinson, George A.; Manokumar, Tharsika; Samadi, Osai; Sandoval, Joanna; Durbano, Sara; Warde, Padraig; Jones, Jennifer M.
- Abstract
<bold>Background: </bold>Strategies to improve bone health care in men receiving androgen deprivation therapy (ADT) are not consistently implemented. The authors conducted a phase 2 randomized controlled trial of 2 education-based models-of-care interventions to determine their feasibility and ability to improve bone health care.<bold>Methods: </bold>A single-center parallel-group randomized controlled trial of men with prostate cancer who were receiving ADT was performed. Participants were randomized 1:1:1 to 1) a patient bone health pamphlet and brief recommendations for their family physician (BHP+FP); 2) a BHP and support from a bone health care coordinator (BHP+BHCC); or 3) usual care. The primary efficacy outcome was receipt of a bone mineral density (BMD) test within 6 months. Secondary efficacy outcomes included guideline-appropriate calcium and vitamin D use and bisphosphonate prescriptions for men at high fracture risk. Feasibility endpoints included recruitment, retention, satisfaction, contamination, and outcome capture. The main analysis used logistic regression with a 1-sided P of .10. The trial is registered at ClinicalTrials.gov (identifier NCT02043236).<bold>Results: </bold>A total of 119 men were recruited. The BHP+BHCC strategy was associated with a greater percentage of men undergoing a BMD test compared with the usual-care group (78% vs 36%; P<.001). BMD ordering also was found to be increased with the BHP+FP strategy (58% vs 36%; P = .047). Both strategies were associated with higher percentages of patients using calcium and vitamin D, but only the BHP+FP arm was statistically significant (P = .039). No men were detected to be at high fracture risk. All but one feasibility endpoint was met.<bold>Conclusions: </bold>Educational strategies to improve bone health care appear feasible and are associated with improved BMD ordering in men receiving ADT. Cancer 2018;124:1132-40. © 2017 American Cancer Society.
- Subjects
PROSTATE cancer patients; PROSTATE cancer treatment; TREATMENT of bone diseases; ANDROGEN drugs; RANDOMIZED controlled trials
- Publication
Cancer (0008543X), 2018, Vol 124, Issue 6, p1132
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.31171