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- Title
Lung cancer in nonsmoking women. Histology and survival patterns.
- Authors
Brownson, Ross C.; Loy, Timothy S.; Ingram, Ellis; Myers, Jeffrey L.; Alavanja, Michael C. R.; Sharp, Donald J.; Chang, Jian C.; Brownson, R C; Loy, T S; Ingram, E; Myers, J L; Alavanja, M C; Sharp, D J; Chang, J C
- Abstract
<bold>Background: </bold>Despite the widespread view that important clinical and etiologic differences exist between histologic categories of lung cancer, few studies have examined the accuracy of hospital-reported pathologic diagnoses of lung cancer.<bold>Methods: </bold>A review of pathologic material and an assessment of survival patterns were conducted in conjunction with a recently completed case-control study of lung cancer among nonsmoking women in Missouri. Using established protocols, tissue slides from tumors of 482 patients were reviewed by 3 pathologists.<bold>Results: </bold>Adenocarcinoma was the most common histologic type among former smokers and lifetime nonsmokers. The overall agreement rate between the original and review diagnoses was 65.6%. The positive predictive value ranged from 0.33 for bronchioalveolar carcinomas to 0.84 for adenocarcinomas. Agreement rates for small, medium, and large hospitals were 63.1, 66.6, and 66.2%, respectively. Survival rates were highest for bronchioalveolar carcinoma and lowest for small cell carcinoma.<bold>Conclusion: </bold>Given the importance of lung cancer to public health and the need to examine risk by histologic type, these data indicate that pathologic review of registry-reported lung cancer cases may be an important component of large scale studies of etiology.
- Publication
Cancer (0008543X), 1995, Vol 75, Issue 1, p29
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19950101)75:1<29::AID-CNCR2820750107>3.0.CO;2-Q