We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases.
- Authors
Grignon, David J.; Ro, Jae Y.; Ayala, Alberto G.; Shum, David T.; Ordóñez, Nelson G.; Logothetis, Christopher J.; Johnson, Douglas E.; Mackay, Bruce; Grignon, D J; Ro, J Y; Ayala, A G; Shum, D T; Ordóñez, N G; Logothetis, C J; Johnson, D E; Mackay, B
- Abstract
Small cell carcinoma of the urinary bladder is an uncommon tumor. The authors report the clinicopathologic findings in a series of 22 cases. Fifteen men and 7 women were studied; their ages ranged from 51 to 87 years (mean, 62.4 years). The most frequent presentation was hematuria (94.4%). At diagnosis, three patients had Stage B disease, six had Stage C, and ten had Stage D (unknown stage in three). Histologically, 6 were oat cell type tumors, 11 were of intermediate cell type, and 5 were of combined cell type. Immunohistochemical studies demonstrated positivity for neuron-specific enolase in ten of ten cases, cytokeratin in seven of ten cases, chromogranin in eight of nine cases, serotonin in seven of nine cases, and S-100 protein in four of ten cases. Neuroendocrine differentiation was seen in five of seven cases examined by electron microscopy. Treatment and follow-up data were available for 19 patients: 10 (52.6%) were dead of disease, 5 (26.3%) were alive and well, 3 (15.8%) were alive with disease, and 1 (5.3%) died of an unrelated cause. The 2-year survival rate was 50% for patients with Stage B, 25% for patients with Stage C, and 33% for patients with Stage D disease. Although overall survival was poor, some cases responded well to therapy. Based on the authors' experience, radical cystectomy with adjuvant chemotherapy appears to be the treatment of choice.
- Publication
Cancer (0008543X), 1992, Vol 69, Issue 2, p527
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19920115)69:2<527::AID-CNCR2820690241>3.0.CO;2-7