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- Title
Soluble interleukin-2 receptors in patients with nasopharyngeal carcinoma.
- Authors
Lai, Kar Neng; Ho, Stephen; Leung, Joseph C. K.; Tsao, Shiu Ying; Lai, K N; Ho, S; Leung, J C; Tsao, S Y
- Abstract
The authors performed a retrospective analysis of serum soluble interleukin-2 receptor (sIL-2R) levels in 72 patients with nasopharyngeal carcinoma (NPC) using an enzyme immunoassay. Their objectives were to determine the value of serum sIL-2R in estimating the tumor burden, and its predictive value in response to therapy and prognosis. The data showed that serum sIL-2R levels in patients were significantly higher than that of healthy controls. The serum levels correlated with clinical staging and hence the tumor burden of NPC. Serial measurement of serum sIL-2R provided an accurate prognostic index of the clinical response to radiotherapy in at least 89% of patients with raised serum sIL-2R at initial diagnosis (defined as mean + 2 SD of healthy controls) and a reliable predictive index in all patients who subsequently developed distant metastasis despite initial radiotherapy. Simultaneous measurement of Epstein-Barr virus-related serology (IgA-VCA and IgG-EA) failed to demonstrate predictive value comparable with that of serum sIL-2R. The authors conclude that monitoring serum sIL-2R levels has clinical and prognostic significance in patients with NPC and that prospective studies are indicated.
- Publication
Cancer (0008543X), 1991, Vol 67, Issue 8, p2180
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19910415)67:8<2180::AID-CNCR2820670829>3.0.CO;2-T