We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Parental Tobacco Smoking and Acute Myeloid Leukemia.
- Authors
Metayer, Catherine; Petridou, Eleni; Mejía Aranguré, Juan Manuel; Roman, Eve; Schüz, Joachim; Magnani, Corrado; Mora, Ana Maria; Mueller, Beth A.; de Oliveira, Maria S. Pombo; Dockerty, John D.; McCauley, Kathryn; Lightfoot, Tracy; Hatzipantelis, Emmanouel; Rudant, Jérémie; Flores-Lujano, Janet; Kaatsch, Peter; Miligi, Lucia; Wesseling, Catharina; Doody, David R.; Moschovi, Maria
- Abstract
The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age <15 years and 13,169 controls. We conducted pooled analyses of CLIC studies, as well as meta-analyses of CLIC and non-CLIC studies. Overall, maternal smoking before, during, or after pregnancy was not associated with childhood AML; there was a suggestion, however, that smoking during pregnancy was associated with an increased risk in Hispanics (odds ratio = 2.08, 95% confidence interval (CI): 1.20, 3.61) but not in other ethnic groups. By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62) and 1.18 (95% CI: 0.92, 1.51) in pooled and meta-analyses, respectively. Overall, increased risks from 1.2- to 1.3-fold were observed for pre- and postnatal smoking (P < 0.05), with higher risks reported for heavy smokers. Associations with paternal smoking varied by histological type. Our analyses suggest an association between paternal smoking and childhood AML. The association with maternal smoking appears limited to Hispanic children, raising questions about ethnic differences in tobacco-related exposures and biological mechanisms, as well as study-specific biases.
- Subjects
CONFIDENCE intervals; ETHNIC groups; HISPANIC Americans; META-analysis; PROBABILITY theory; RESEARCH funding; SMOKING; WHITE people; SOCIOECONOMIC factors; ACUTE myeloid leukemia; PRENATAL exposure delayed effects; ODDS ratio
- Publication
American Journal of Epidemiology, 2016, Vol 184, Issue 4, p261
- ISSN
0002-9262
- Publication type
Article
- DOI
10.1093/aje/kww018