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- Title
Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy.
- Authors
Jenson, Hal B.; Gauntt, Charles J.; Easley, Kirk A.; Pitt, Jane; Lipshultz, Steven E.; McIntosh, Kenneth; Shearer, William T.; Pediatric Pulmonary and Cardiovascular Complication of HIV-1 Infection Study Group
- Abstract
In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P=.75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.
- Subjects
COXSACKIEVIRUSES; HIV; CARDIOMYOPATHIES; HIV infection complications; COMPARATIVE studies; COXSACKIEVIRUS diseases; RESEARCH methodology; MEDICAL cooperation; RESEARCH; LOGISTIC regression analysis; EVALUATION research; CASE-control method; DISEASE complications
- Publication
Journal of Infectious Diseases, 2002, Vol 185, Issue 12, p1798
- ISSN
0022-1899
- Publication type
journal article