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- Title
Neurotoxicity of perineural vs intraneural-extrafascicular injection of liposomal bupivacaine in the porcine model of sciatic nerve block.
- Authors
Damjanovska, M.; Cvetko, E.; Hadzic, A.; Seliskar, A.; Plavec, T.; Mis, K.; Vuckovic Hasanbegovic, I.; Stopar Pintaric, T.
- Abstract
Liposomal bupivacaine is a prolonged-release local anaesthetic, the neurotoxicity of which has not yet been determined. We used quantitative histomorphometric and immunohistochemical analyses to evaluate the neurotoxic effect of liposomal bupivacaine after perineural and intraneural (extrafascicular) injection of the sciatic nerve in pigs. In this double-blind prospective randomised trial, 4 ml liposomal bupivacaine 1.3% was injected either perineurally (n = 5) or intraneurally extrafascicularly (n = 5). Intraneural-extrafascicular injection of saline (n = 5) was used as a control. After emergence from anaesthesia, neurological examinations were conducted over two weeks. After harvesting the sciatic nerves, no changes in nerve fibre density or myelin width indicative of nerve injury were observed in any of the groups. Intraneural injections resulted in longer sensory blockade than perineural (p < 0.003) without persistent motor or sensory deficit. Sciatic nerve block with liposomal bupivacaine in pigs did not result in histological evidence of nerve injury.
- Subjects
BUPIVACAINE; NEUROTOXICOLOGY; CONDUCTION anesthesia complications; NERVE block; LIPOSOMES; SCIATIC nerve; ANIMAL experimentation; COMPARATIVE studies; FASCIAE (Anatomy); INJECTIONS; LOCAL anesthetics; RESEARCH methodology; MEDICAL cooperation; ARTIFICIAL membranes; RESEARCH; SWINE; EVALUATION research
- Publication
Anaesthesia, 2015, Vol 70, Issue 12, p1418
- ISSN
0003-2409
- Publication type
journal article
- DOI
10.1111/anae.13189