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- Title
Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results.
- Authors
Toyoda, Kosuke; Maeshima, Akiko Miyagi; Nomoto, Junko; Suzuki, Tomotaka; Yuda, Sayako; Yamauchi, Nobuhiko; Taniguchi, Hirokazu; Makita, Shinichi; Fukuhara, Suguru; Munakata, Wataru; Maruyama, Dai; Tobinai, Kensei; Kobayashi, Yukio
- Abstract
Translocation (11;18)(q21;q21) is found in mucosa-associated lymphoid tissue (MALT) lymphoma, resulting in API2/MALT1 gene fusion. It is known that t(11;18)-positive MALT lymphoma shows a tendency to disseminate and be resistant to Helicobacter pylori eradication by antibiotics. However, the prognostic features including recurrence and histological transformation (HT) remain unknown. We conducted a single-institute retrospective analysis of 464 patients with newly diagnosed MALT lymphoma, evaluating the impact of t(11;18) on clinical outcomes. One hundred and six patients were screened for the translocation by fluorescence in situ hybridization and/or reverse transcriptase-polymerase chain reaction. Of these patients, 26 patients (25%) were diagnosed as MALT lymphoma with t(11;18). The patients had a significantly shortened progression-free survival (PFS at 10 years; 26% v 57%; P = 0.004) compared to those without t(11;18). However, this did not translate into overall survival or incidence of HT. We confirmed previous reports stating that t(11;18)-positive MALT lymphoma showed disseminated disease and refractoriness to H. pylori eradication therapy. Patients with t(11;18) had more frequent monoclonal gammopathy, especially of IgM subtype (31% v 8%; P = 0.008), some of which developed class switch. These findings characterize the features of t(11;18)-positive MALT lymphoma, suggesting that it comprises a distinct clinical entity of MALT lymphoma.
- Subjects
MUCOSA-associated lymphoid tissue lymphoma; FLUORESCENCE in situ hybridization; GENE fusion; LYMPHOID tissue; CHROMOSOMES; REVERSE transcriptase polymerase chain reaction; RESEARCH; CLINICAL trials; RESEARCH methodology; B cell lymphoma; PROGNOSIS; RETROSPECTIVE studies; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; CHROMOSOME abnormalities; IMPACT of Event Scale; RESEARCH funding; POLYMERASE chain reaction; LONGITUDINAL method
- Publication
Annals of Hematology, 2019, Vol 98, Issue 7, p1675
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s00277-019-03671-5