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- Title
Causal Prophylactic Efficacy of Primaquine, Tafenoquine, and Atovaquone-Proguanil Against Plasmodium cynomolgi in a Rhesus Monkey Model.
- Authors
DiTusa, Charles; Kozar, Michael P.; Pybus, Brandon; Sousa, Jason; Berman, Jonathan; Gettayacamin, Montip; Im-erbsin, Rawiwan; Tungtaeng, Anchalee; Ohrt, Colin
- Abstract
Since the 1940s, the large animal model to assess novel causal prophylactic antimalarial agents has been the Plasmodium cynomolgi sporozoite-infected Indian-origin rhesus monkey. In 2009 the model was reassessed with 3 clinical standards: primaquine (PQ), tafenoquine (TQ), and atovaquone-proguanil. Both control monkeys were parasitemic on day 8 post-sporozoite inoculation on day 0. Primaquine at 1.78 mg base/kg/day on days (−1) to 8 protected 1 monkey and delayed parasitemia patency of the other monkey to day 49. Tafenoquine at 6 mg base/kg/day on days (−1) to 1 protected both monkeys. However, atovaquone-proguanil at 10 mg atovaquone/kg/day on days (−1) to 8 did not protect either monkey and delayed patency only to days 18-19. Primaquine and TQ at the employed regimens are proposed as appropriate doses of positive control drugs for the model at present.
- Subjects
ANTIMALARIALS; PLASMODIUM; SPOROZOITES; RHESUS monkeys; MONKEY diseases
- Publication
Journal of Parasitology, 2014, Vol 100, Issue 5, p671
- ISSN
0022-3395
- Publication type
Article
- DOI
10.1645/13-480.1