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- Title
Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil.
- Authors
Donald, Graciela Rocha; Fernandes, Patrícia Dias; Boylan, Fabio
- Abstract
Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO). The major component present in the essential oil was beta-phellandrene (29.39%). Its antinociceptive activity was tested through animal models (formalin-, capsaicin-, and glutamate-induced paw licking and hot plate). The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.
- Subjects
ASIA; JAPAN; PHYTOTHERAPY; FATS &; oils; ALTERNATIVE medicine; ANIMAL experimentation; BIOLOGICAL models; GENE expression; MICE; NOCICEPTORS; NONSTEROIDAL anti-inflammatory agents; RESEARCH funding; EVIDENCE-based medicine; CYCLOOXYGENASE 2; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2016, Vol 2016, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2016/3840398