We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice.
- Authors
Sacchet, Cassia; Mocelin, Ricieri; Sachett, Adrieli; Bevilaqua, Fernanda; Chitolina, Rafael; Kuhn, Fernanda; Boligon, Aline Augusti; Athayde, Margareth Linde; Roman Junior, Walter Antonio; Rosemberg, Denis Broock; Dal Magro, Jacir; Conterato, Greicy Michelle Marafiga; Piato, Angelo L.
- Abstract
The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named “jabuticabeira” in Brazil and is used in folk medicine to treat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study evaluated the antidepressant-like and antioxidant effects of P. trunciflora (PT) aqueous extract, in which five different anthocyanins were identified. PT showed significant ferric-reduction power and DPPH radical scavenging activity in vitro and reduced lipid peroxidation both in vitro and ex vivo. At the behavioural level, PT (400 and 800 mg/kg, i.p.) dose-dependently reduced immobility time in the tail suspension test in Swiss male mice. The identification of bioactive compounds accompanied by the in vitro and ex vivo antioxidant activity of PT suggests that these activities might be related to the antidepressant-like activity of P. trunciflora.
- Subjects
BRAZIL; ANIMAL experimentation; ANTIDEPRESSANTS; ANTIOXIDANTS; FRUIT; IRON compounds; LIPID peroxidation (Biology); MICE; ORGANIC compounds; PLANT extracts; FREE radical scavengers; IN vitro studies
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, Vol 2015, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2015/601503