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- Title
Identification of the causal relationship between sleep quality, insomnia, and oral ulcers.
- Authors
Liu, Qianxi; Wang, Jiongke; Liu, Tiannan; Zeng, Xin; Zhang, Xuefeng
- Abstract
Background: Multiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases. Methods: We utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652). Results: Our results revealed a negative genetic correlation between sleep duration and mouth ulcer (genetic correlation: -0.09, P = 0.007), while a positive genetic correlation between insomnia and mouth ulcer was observed (genetic correlation: 0.18, P = 2.51E-06). Furthermore, we demonstrated that longer sleep duration is significantly associated with a reduced risk of mouth ulcers (OR: 0.67, 95% CI: 0.54–0.83, P = 2.84E-04), whereas insomnia is nominally associated with an increased risk of mouth ulcers (OR: 1.40, 95% CI: 1.01–1.95, P = 0.044). In contrast, no significant association was detected between sleep quality and periodontal disease or oral cavity cancer. Conclusions: This work provides robust evidence to support the notion that enhanced sleep quality may confer a decreased risk of oral ulcers, thereby bearing considerable clinical relevance.
- Subjects
RISK factors of periodontal disease; SLEEP quality; CANKER sores; CONFIDENCE intervals; MOUTH tumors; RISK assessment; SLEEP duration; ATTRIBUTION (Social psychology); DESCRIPTIVE statistics; RESEARCH funding; INSOMNIA; ODDS ratio; SECONDARY analysis; DISEASE risk factors; DISEASE complications
- Publication
BMC Oral Health, 2023, Vol 23, Issue 1, p1
- ISSN
1472-6831
- Publication type
Article
- DOI
10.1186/s12903-023-03417-w