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- Title
Synthesis and antimicrobial studies of novel (2-benzylidene)-phenylureido-thiazolopyrimidine derivatives.
- Authors
Maddila, Suresh; Lavanya, Palakondu; Jonnalagadda, Sreekanth B.; Chunduri, Venkatarao
- Abstract
A new series of ethyl 2-(substitutedbenzylidene)-5-methyl-3-oxo-7-(4-(3-phenylureido) phenyl)-3,7-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate derivatives (7a-k) were synthesized. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Streptococcus pyogenes and for antifungal activity against Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Penicillium marneffei and Mucor. Compounds 7b, 7e, 7f, 7g, 7h and 7j showed excellent in vitro antibacterial activity and antifungal activity compared with the standard drugs.
- Subjects
ANTI-infective agents; CHEMICAL synthesis; BENZYLIDENE compounds; PYRIMIDINE derivatives; CARBOXYLATE derivatives; INFRARED spectroscopy; STREPTOCOCCUS pyogenes; ASPERGILLUS flavus
- Publication
Chemija, 2012, Vol 23, Issue 2, p124
- ISSN
0235-7216
- Publication type
Article