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- Title
Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats.
- Authors
Hansen, Gitte; Jelsing, Jacob; Vrang, Niels
- Abstract
Aim:To validate the gubra DIO-rats as a useful animal model of human obesity.Methods:The gubra diet-induced obesity (DIO) rat model was based on male Sprague-Dawley rats with ad libitum access to regular chow and a palatable diet rich in fat and sugar. To evaluate the versatility of the gubra DIO-rats as a valid model of human obesity syndrome, the efficacy of 2 weight loss compounds liraglutide and sibutramine with different mechanisms of action were examined in 7-month-old gubra DIO-rats. Liraglutide (200 μg/kg, sc) was administered bi-daily, and sibutramine (5 mg/kg, po) was administered once daily for 23 d.Results:Both the compounds effectively reduced the food intake, body weight and total fat mass as measured by nuclear magnetic resonance. Whereas the 5-HT reuptake inhibitor/5-HT receptor agonist sibutramine reduced the intake of both chow and the gubra-diet, the GLP-1 analogue liraglutide predominantly reduced the intake of the highly palatable diet, indicating a shift in food preference. Sibutramine lowered the insulin sensitivity index, primarily via reductions in glucose-stimulated insulin secretion.Conclusion:This animal model responds well to 2 weight loss compounds with different mechanisms of action. Moreover, the gubra DIO-rat can be particularly useful for the testing of compounds with potential effects on diet preference.
- Subjects
SIBUTRAMINE; DRUG efficacy; INGESTION; BODY weight; GLUCOSE tolerance tests; NUTRITIONALLY induced diseases; OBESITY; ANIMAL models in research; SPRAGUE Dawley rats
- Publication
Acta Pharmacologica Sinica, 2012, Vol 33, Issue 2, p194
- ISSN
1671-4083
- Publication type
Article
- DOI
10.1038/aps.2011.168