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- Title
Genetic influence of meningioma on cisplatin resistance: a Mendelian randomization analysis.
- Authors
Yu, Kefu; Li, Ziming; Shi, Weizhong; Yang, Shuxian; Zhao, Zhigang; Yang, Li
- Abstract
Background: Although various aspects of cisplatin resistance have been studied, the impact of genetic variations still needs to be explored. Aim: This study aimed to investigate the impact of cisplatin on meningiomas using a two-sample Mendelian randomization (MR) approach, employing genetic variants associated with cisplatin use as instrumental variables. Method: We conducted a two-sample MR analysis using genome-wide association study (GWAS) data. Instrumental variables were derived from single-nucleotide polymorphisms (SNPs) associated with meningioma to estimate the causal relationship with cisplatin resistance. Sensitivity analyses were performed to confirm the findings. Results: Genetic predisposition to meningioma significantly increased the risk of cisplatin resistance (odds ratio (OR): 1.63; 95% confidence interval (CI) 1.44–1.85, P < 0.05). Sensitivity analyses supported the causal link. Conclusion: This MR study suggests that genetic predisposition to meningioma increases susceptibility to cisplatin resistance. Further research is needed to uncover the mechanisms behind these causal effects.
- Subjects
MENDEL'S law; GENOME-wide association studies; GENETIC variation; SINGLE nucleotide polymorphisms; CISPLATIN
- Publication
International Journal of Clinical Pharmacy, 2024, Vol 46, Issue 5, p1225
- ISSN
2210-7703
- Publication type
Article
- DOI
10.1007/s11096-024-01762-6