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- Title
TO ASSESS THE ANALGESIC EFFICACY OF ORAL CLONIDINE VS INTRATHECAL CLONIDINE ADDED AS AN ADJUVANT TO 0.5% HYPERBARIC BUPIVACAINE IN CESAREAN SECTION-A PROSPECTIVE RANDOMIZED DOUBLE BLINDED STUDY.
- Authors
M, Vignesh T; patil, Rashmi.; Bharamagoudar, Aishwarya; Harshitha; B, Jyothi
- Abstract
Aims: We aimed to compare the analgesic efficacy of oral clonidine vs intrathecal clonidine added as an adjuvant to 0.5% hyperbaric bupivacaine spinal anesthesia in cesarean section Materials and Methods: A prospective randomized double blind controlled studyenrolled 50 patients for elective caesarean sections under spinal anesthesia and were allocated into 2 groups (25 each) after fulfilling the inclusion and exclusion criteria. Group O received 0.5% hyperbaric bupivacaine 2cc(10mg) plus 0.5 cc NS intrathecally and 200µg oral clonidine was given 90 mins before spinal anesthesia and group I received 0.5 % Hyperbaric bupivacaine 2cc(10mg) + 45 µg (0.5cc) of clonidine intrathecally with oral vitamin c tablets 90 mins before spinal anesthesia. Results: Both the groups had comparable demographics in age, height,weight, BMI. There was a statistically significant difference in terms of duration of analgesia between the two groups. Duration of analgesia was prolonged more in Group I than in Group O with a p value 0.0001.There was a statistically significant difference in terms of onset of sensory and motor blockade which was faster in Group I than in Group O. (P=0.0001). There was a statistically significant difference in terms of duration of sensory and motor blockade which was prolonged in Group I than in Group O. (P=0.0001). There was a significant reduction in pulse rate and hypotensive episodes encountered with Group O than Group I which was statistically significant. The sedation, fetal well being and adverse effects were all comparable between the two groups. Conclusion: Intrathecal clonidine when added as an adjuvant to hyperbaric bupivacaine prolongs the duration of analgesia, sensory and motor block than oral clonidine without significant adverse effects.
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 8, p1466
- ISSN
0975-3583
- Publication type
Article