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- Title
Protective Effects of Cyphomandra betacea Extract Against Hydrogen Peroxide-induced Oxidative Stress in 3T3 Cells and Synergistic Anticancer Properties in HepG<sub>2</sub> and MDA-MB-231 Cell Lines.
- Authors
Mutalib, Maisarah Abdul; Rahmat, Asmah; Khan, Muhammad Shuaib; Zaman, Ali; Malik, Muhammad Inamullah; Muhammad, Khalid; Khan, Shabnam Razzaq; Malik, Shomaila Noreen; Rustam, Saqib Ali
- Abstract
Using the MTT 3-(4, 5-dimethylthiazol-2yl-2, 5-diphenyltetrazolium bromide) assay induced by hydrogen peroxide (H2O2) and the ability to increase the cytotoxicity of doxorubicin in HepG2 and MDA-MB-231 cells, the protective effects of ethanolic extract of tamarillo were assessed in the current study. The cells were pre-treated with tamarillo ethanolic extract at 10 g/mL for 4 h before being exposed to 0.6 mM H2O2 for 3 h showed the greatest protection, with a significant increase (P 0.05) in cell viability of 79% compared to the control (57%). The results support a role that cyto-protective effect of tamarillo and doxorubicin which low in toxicity opens a new possible approach for possible future use in conventional chemotherapeutic drugs and radiation therapy.
- Subjects
RADIOTHERAPY; HYDROGEN peroxide; CYTOTOXINS; DRUG therapy; CELL survival; DOXORUBICIN
- Publication
Pakistan Journal of Scientific & Industrial Research Series B: Biological Sciences, 2024, Vol 67, Issue 2, p167
- ISSN
2221-6421
- Publication type
Article