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- Title
Single-cell RNA sequencing illuminates the ontogeny, conservation and diversification of cartilaginous and bony fish lymphocytes.
- Authors
Wang, Hong-Yan; Chen, Jian-Yang; Li, Yanan; Zhang, Xianghui; Liu, Xiang; Lu, Yifang; He, Hang; Li, Yubang; Chen, Hongxi; Liu, Qun; Huang, Yingyi; Jia, Zhao; Li, Shuo; Zhang, Yangqing; Han, Shenglei; Jiang, Shuhong; Yang, Mingming; Zhang, Yingying; Zhou, Li; Tan, Fujian
- Abstract
Elucidating cellular architecture and cell-type evolution across species is central to understanding immune system function and susceptibility to disease. Adaptive immunity is a shared trait of the common ancestor of cartilaginous and bony fishes. However, evolutionary features of lymphocytes in these two jawed vertebrates remain unclear. Here, we present a single-cell RNA sequencing atlas of immune cells from cartilaginous (white-spotted bamboo shark) and bony (zebrafish and Chinese tongue sole) fishes. Cross-species comparisons show that the same cell types across different species exhibit similar transcriptional profiles. In the bamboo shark, we identify a phagocytic B cell population expressing several pattern recognition receptors, as well as a T cell sub-cluster co-expressing both T and B cell markers. In contrast to a division by function in the bony fishes, we show close linkage and poor functional specialization among lymphocytes in the cartilaginous fish. Our cross-species single-cell comparison presents a resource for uncovering the origin and evolution of the gnathostome immune system. Both cartilaginous and bony fishes have adaptive immune cells, but the evolutionary features of these diverse cell populations remain understudied. Here the authors report single-cell RNA sequencing atlas of both species to define these features and to find reduced evolutionary diversification of immune cells in cartilaginous fishes.
- Subjects
CHONDRICHTHYES; PATTERN perception receptors; OSTEICHTHYES; RNA sequencing; CELL populations
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-51761-4