We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypoxia as a Target for Combination with Transarterial Chemoembolization in Hepatocellular Carcinoma.
- Authors
Wang, Zizhuo; Li, Qing; Liang, Bin
- Abstract
Hypoxia is a hallmark of solid tumors, including hepatocellular carcinoma (HCC). Hypoxia has proven to be involved in multiple tumor biological processes and associated with malignant progression and resistance to therapy. Transarterial chemoembolization (TACE) is a well-established locoregional therapy for patients with unresectable HCC. However, TACE-induced hypoxia regulates tumor angiogenesis, energy metabolism, epithelial-mesenchymal transition (EMT), and immune processes through hypoxia-inducible factor 1 (HIF-1), which may have adverse effects on the therapeutic efficacy of TACE. Hypoxia has emerged as a promising target for combination with TACE in the treatment of HCC. This review summarizes the impact of hypoxia on HCC tumor biology and the adverse effects of TACE-induced hypoxia on its therapeutic efficacy, highlighting the therapeutic potential of hypoxia-targeted therapy in combination with TACE for HCC.
- Subjects
HYPOXIA-inducible factor 1; HYPOXIA-inducible factors; CHEMOEMBOLIZATION; TREATMENT effectiveness; EPITHELIAL-mesenchymal transition
- Publication
Pharmaceuticals (14248247), 2024, Vol 17, Issue 8, p1057
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph17081057