We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prediktivni značaj mutacija u K-ras onkogenu za hemioterapijske protokole na bazi platine kod bolesnika sa uznapredovalim nesitnoćelijskim karcinomom pluća.
- Authors
Cvetković, Gordana; Plavec, Goran; Tomić, Ilija; Ilić, Vesna; Magić, Zvonko; Tatomirović, Željka; Novković, Dobrivoje; Milić, Rade; Karličić, Vukojica
- Abstract
Beckground/Aim. K-ras oncogene is mutated in about 20% of lung cancer. The purpose of this study was to investigate the predictive significance for therapeutic re-sponse of K-ras mutations in advanced non-small cell lung cancer (NSCLC) patients. Methods. Bronchial as-pirate samples were assessed prior to platinum-based chemotherapy start in 39 patients with stage IIIb or IV NSCLC. K-ras mutations at codons 12 and 13 were analyzed by single strand conformation polymorphisam (SSCP) and allele specific oligonucleozide hybridisation of polymerase chain reaction (PCR) of the patient's DNA present in bronchial aspirate. After two cycles of chemotherapy the patients were subjected to response evaluation. Results. Of 39 patients 10 (25.5%) demon-strated K-ras mutations, while 29 (74.4%) patients had not. There were no significant differences between these two groups of patients with respect to baseline patient caracteristics. Partial response to the therapy had 16 (41%), no changes 14 (36%), and progressive disease 9 (23%) patients. There was a tendency to higher response rate for patients without K-ras mutations versus those with mutations, but not statistically significant (p = 0.14). Conclusion. There was no significant predictive value for therapeutic response of K-ras mutations for advanced non-small cell lung cancer.
- Subjects
GENETIC mutation; CANCER chemotherapy; CANCER patients; LUNG cancer; RAS oncogenes; POLYMERASE chain reaction; CANCER treatment
- Publication
Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, 2009, Vol 66, Issue 2, p149
- ISSN
0042-8450
- Publication type
Article
- DOI
10.2298/VSP0902149C