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- Title
Icaritin Inhibits Skin Fibrosis through Regulating AMPK and Wnt/β-catenin Signaling.
- Authors
Li, Ming; Liu, Qingmei; He, Shan; Kong, Xiangzhen; Lin, Jinpei; Huang, Yan; Wu, Wenyu; Wu, Jinfeng
- Abstract
Skin fibrosis is one of the major features of scleroderma. WNT/β-catenin signaling is associated with the progression of skin fibrosis. In this study, we aimed to determine the effect of icaritin (IT), a natural compound, on scleroderma-related skin fibrosis and its mechanisms. We found that IT could reduce the expression of COL1A1, COL1A2, COL3A1, CTGF, and α-SMA in human foreskin fibroblasts (HFF-1 cells), scleroderma skin fibroblasts (SSF cells), and TGF-β-induced HFF-1 cells. Wnt/β-catenin signaling was shown to be suppressed by IT. Additionally, IT activated AMPK signaling in HFF-1 cells. In conclusion, IT has an anti-skin fibrotic effect through activation of AMPK signaling and inhibition of WNT/β-catenin signaling. Our findings indicate the potential role of IT in the treatment of scleroderma and provide novel insight for the selection of drug therapy for scleroderma.
- Subjects
FIBROSIS; WNT proteins; DRUG therapy; CELL communication; FIBROBLASTS
- Publication
Cell Biochemistry & Biophysics, 2021, Vol 79, Issue 2, p231
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-020-00952-z