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- Title
Therapeutic Effects of Sodium Para-Aminosalicylic Acid on Cognitive Deficits and Activated ERK1/2-p90<sup>RSK</sup>/NF-κB Inflammatory Pathway in Pb-Exposed Rats.
- Authors
Lu, Li-li; Zhang, Yu-wen; Li, Zhao-cong; Fang, Yuan-yuan; Wang, Lei-lei; Zhao, Yue-song; Li, Shao-jun; Ou, Shi-yan; Aschner, Michael; Jiang, Yue-ming
- Abstract
Lead (Pb) is a toxic heavy metal and environmental pollutant that adversely affects the nervous system. However, effective therapeutic drugs for Pb-induced neurotoxicity have yet to be developed. In the present study, we investigated the ameliorative effect of sodium para-aminosalicylic acid (PAS-Na) on Pb-induced neurotoxicity. Male Sprague–Dawley rats were treated with (CH3COO)2 Pb•4H2O (6 mg/kg) for 4 weeks, followed by 3 weeks of PAS-Na (100, 200, and 300 mg/kg). The results showed that subacute Pb exposure significantly decreased rats body-weight gains and increased liver coefficient, and impaired spatial learning and memory. HE staining showed that Pb damaged the structure of the hippocampus. Moreover, Pb activated the ERK1/2-p90RSK/ NF-κB pathway concomitant with increased inflammatory cytokine IL-1β levels in rat hippocampus. PAS-Na reversed the Pb-induced increase in the liver coefficient as well as the learning and memory deficits. In addition, PAS-Na reduced the phosphorylation of ERK1/2, p90RSK and NF-κB p65, decreasing IL-1β levels in hippocampus. Our findings indicated that PAS-Na showed efficacy in reversing Pb-induced rats cognitive deficits and triggered an anti-inflammatory response. Thus, PAS-Na may be a promising therapy for treating Pb-induced neurotoxicity.
- Subjects
RATS; POLLUTANTS; TREATMENT effectiveness; SODIUM; NERVOUS system; MEMORY disorders; HEAVY metals
- Publication
Biological Trace Element Research, 2022, Vol 200, Issue 6, p2807
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-021-02874-0