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- Title
Actin‑like protein 8 executes a promoting function in the malignant progression of endometrial cancer: identification of a promising biomarker.
- Authors
Li, Li; Cheng, Guang-Hui; Chen, Chen; Ma, De-Mei; Deng, Xin-Chao
- Abstract
Endometrial cancer (EC) is generally considered as a disease that affects older women. We attempt to explore the role of actin‑like protein 8 (ACTL8) in EC and how it achieves its function. Based on the data from The Cancer Genome Atlas (TCGA), we found that ACTL8 expression was up-regulated in EC tissues and correlated with shorter overall survival of EC patients. ACTL8 expression was significantly associated with age, clinical-stage, or grade. Cox proportional hazards model analysis revealed that ACTL8 expression, grade, and clinical-stage were promising independent prognostic factors of EC. Knockdown of ACTL8 repressed the proliferative, migrating and invading capabilities of human EC cell lines KLE and Ishikawa. Silencing ACTL8 up-regulated the negative cell cycle regulator p21 and epithelial marker E-cadherin, and down-regulated the positive cell cycle regulator Cyclin A, mesenchymal markers MMP-9 and N-cadherin in KLE cells. Collectively, these outcomes illustrated that ACTL8 might act as a tumor facilitator during EC progression. Actin-like protein 8 promotes the growth and migration of endometrial cancer (EC) cells.
- Subjects
ENDOMETRIAL cancer; PROPORTIONAL hazards models; CANCER invasiveness; OLDER women; CELL cycle; MATERNAL age
- Publication
Bioscience, Biotechnology & Biochemistry, 2020, Vol 84, Issue 6, p1160
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2020.1736508