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- Title
Three new flavonol glycosides from Fissistigma pallens.
- Authors
Nhiem, Nguyen Xuan; Thinh, Ngo Sy; Thu, Nguyen Thi Bich; Anh, Luu The; Minh Ngoc, Tran; Tai, Bui Huu; Yen, Pham Hai; Kiem, Phan Van; Van Minh, Chau; Park, Seonju; Kim, Seung Hyun
- Abstract
Three new flavonol glycosides, fissflavosides A-C (1–3), together with six known flavonol glycosides, kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (4), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside (5), kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (6), rhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (7), rutin (8), and isorhamnetin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-galactopyranoside (9) were isolated from the methanol extract of the Fissistigma pallens leaves. Their chemical structures were determined by 1D-, 2D-NMR, and MS data as well as in comparison with reported data in the literature. Compounds 1–9 showed weak cytotoxic activity on three human cancer cell lines, HT-29, A-2058, A-549 with IC50 ranging from 134.6 to 162.6 µM. In addition, the antioxidant capacities of compounds were also tested by ORAC assay. All compounds showed significant antioxidant with trolox equivalents ranging from 4.4 to 8.6 µM at the concentration of 1.0 µM. The results indicated 7 and 8 having meaningful reducing capacity of copper (I) ions of 2.7 to 6.9 µM at the concentrations of 1 and 2 µM. Compounds 1-3 newly isolated from the leaves of Fissistigma pallens and showed significant antioxidant activity.
- Subjects
FLAVONOL glycosides; GLYCOSIDES; OXIDANT status; CHEMICAL structure; CELL lines; CANCER cells
- Publication
Bioscience, Biotechnology & Biochemistry, 2019, Vol 83, Issue 12, p2177
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2019.1654848