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- Title
Tripterygium regelii decreases the biosynthesis of triacylglycerol and cholesterol in HepG2 cells.
- Authors
Kang, Myung-Ji; Kwon, Eun-Bin; Yuk, Heung Joo; Ryu, Hyung Won; Kim, Soo-Yeon; Lee, Mi-Kyeong; Moon, Dong-Oh; Lee, Su Ui; Oh, Sei-Ryang; Lee, Hyun-Sun; Kim, Mun-Ock
- Abstract
In the course of screening to find a plant material decreasing the activity of triacylglycerol and cholesterol, we identifiedTripterygium regelii(TR). The methanol extract of TR leaves (TR-LM) was shown to reduce the intracellular lipid contents consisting of triacylglycerol (TG) and cholesterol in HepG2 cells. TR-LM also downregulated the mRNA and protein expression of the lipogenic genes such as SREBP-1 and its target enzymes. Consequently, TR-LM reduced the TG biosynthesis in HepG2 cells. In addition, TR-LM decreased SREBP2 and its target enzyme HMG-CoA reductase, which is involved in cholesterol synthesis. In this study, we evaluated that TR-LM attenuated cellular lipid contents through the suppression ofde novoTG and cholesterol biosynthesis in HepG2 cells. All these taken together, TR-LM could be beneficial in regulating lipid metabolism and useful preventing the hyperlipidemia and its complications, in that liver is a crucial tissue for the secretion of serum lipids. The methanol extract ofTripterygium regeliileaves reduced intracellular contents of TG and cholesterol in HepG2 cells.
- Subjects
TRIGLYCERIDES; CHOLESTEROL; BIOSYNTHESIS
- Publication
Bioscience, Biotechnology & Biochemistry, 2017, Vol 81, Issue 12, p2285
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2017.1390392