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- Title
High‐Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads.
- Authors
Tu, Noah P.; Dombrowski, Amanda W.; Goshu, Gashaw M.; Vasudevan, Anil; Djuric, Stevan W.; Wang, Ying
- Abstract
Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents on micro‐ and nanomole scale prevents the full utilization of reaction screening technologies. We herein report the development of a technology in which glass beads coated with solid chemical reagents (ChemBeads) enable the delivery of nanomole quantities of solid chemical reagents efficiently. By exploring the concept of preferred screening sets, the flexibility and generality of this technology for high‐throughput reaction screening was validated.
- Subjects
CHEMICAL reagents; GLASS beads; COATING processes; MATHEMATICAL optimization; SOLID state chemistry
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 24, p8071
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201900536