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- Title
Peptide Logic Circuits Based on Chemoenzymatic Ligation for Programmable Cell Apoptosis.
- Authors
Li, Yong; Sun, Sujuan; Fan, Lin; Hu, Shanfang; Huang, Yan; Zhang, Ke; Nie, Zhou; Yao, Shouzhou
- Abstract
A novel and versatile peptide-based bio-logic system capable of regulating cell function is developed using sortase A (SrtA), a peptide ligation enzyme, as a generic processor. By modular peptide design, we demonstrate that mammalian cells apoptosis can be programmed by peptide-based logic operations, including binary and combination gates (AND, INHIBIT, OR, and AND-INHIBIT), and a complex sequential logic circuit (multi-input keypad lock). Moreover, a proof-of-concept peptide regulatory circuit was developed to analyze the expression profile of cell-secreted protein biomarkers and trigger cancer-cell-specific apoptosis.
- Subjects
PEPTIDES; APOPTOSIS; CELL death; CELL physiology; PEPTIDE analysis
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 47, p15084
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201708327