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- Title
Bicontinuous Nanoporous Frameworks: Caged Longevity for Enzymes.
- Authors
Bae, Jae ‐ Sung; Jeon, Eunkyung; Moon, Su ‐ Young; Oh, Wangsuk; Han, Sun ‐ Young; Lee, Jeong Hun; Yang, Sung Yun; Kim, Dong ‐ Myung; Park, Ji ‐ Woong
- Abstract
The preparation of bicontinuous nanoporous covalent frameworks, which are promising for caging active enzymes, is demonstrated. The frameworks have three- dimensionally continuous, hydrophilic pores with widths varying between 5 and 30 nm. Enzymes were infiltrated into the bicontinuous pore by applying a pressured enzyme solution. The new materials and methods allowed the amount of caged proteins to be controlled precisely. The resulting enzyme-loaded framework films could be recycled many times with nearly no loss of catalytic activity. Entropic trapping of proteins by a bicontinuous pore with the right size distribution is an unprecedented strategy toward facile in vitro utilization of biocatalysts.
- Subjects
NANOPOROUS materials; ENZYMES; HYDROPHILIC compounds; COVALENT bonds; CATALYSIS
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 38, p11667
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201605609