We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex.
- Authors
Cheng, Li ‐ Jie; Cordier, Christopher J.
- Abstract
A catalytic method for the nucleophilic fluorination of propargylic electrophiles is described. Our protocol involves the use of a Cu(NHC) complex as the catalyst and is suitable for the preparation of secondary and tertiary propargylic fluorides without the formation of isomeric fluoroallenes. Preliminary mechanistic investigations suggest that fluorination proceeds via copper acetylides and that cationic species are involved.
- Subjects
CATALYSIS research; NUCLEOPHILES; ELECTROPHILES; FLUORIDES; HETEROCYCLIC compounds; CARBENES
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 46, p13938
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201506882