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- Title
An Enantioselective Synthesis of Spirobilactams through Copper-Catalyzed Intramolecular Double N-Arylation and Phase Separation.
- Authors
Liu, Jianguang; Tian, Yingying; Shi, Jialing; Zhang, Shasha; Cai, Qian
- Abstract
Spirobicyclic structures are versatile building blocks for functional chiral molecules. An enantioselective synthesis of chiral spirobilactams via a copper-catalyzed double N-arylation was developed. Amplification of solution ee by in situ precipitation of the racemate was observed with this method and enantioenriched spirobilactams were obtained with excellent ee values through simple solid-solution phase separation.
- Subjects
SPIRO compounds; ENANTIOSELECTIVE catalysis; COPPER catalysts; ARYLATION; PHASE separation
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 37, p11067
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504589